ATP6AP2 and familial dilated cardiomyopathy: In our study, the results of immunohistochemical staining showed that PRR overexpression in DCM rats would exacerbate YAP expression in the myocardium; the same trend is displayed in high glucose stimulated CFs, and the results of immunofluorescence showed that upregulated PRR by Ad-PRR could further increase YAP expression under high glucose conditions.