The groups with high NLRC5 expression and low NLRC5 methylation showed significantly better prognosis than the low NLRC5 expression group and high NLRC5 methylation group respectively (HR = 0.45 and HR = 2.31) (Fig. 4a), supporting previous reports that NLRC5 expression and methylation is correlated with prognosis of melanoma patients24. Here, NLRC5 is linked to melanoma.