Plk1 expression was increased in tumor samples of metastatic patients treated with sunitinib in a neoadjuvant setting (a rare procedure for inoperable patients bearing large tumors, 8 samples out of 3000 samples of ccRCC from 10 cancer centers in France22) and the relapse rapidly followed surgery although sunitinib, the reference treatment, was maintained as an adjuvant treatment22 (Supplementary Fig. 6a). The gene discussed is PLK1; the disease is neoplasm.