However, several hypoxia-related characteristics are associated with fast tumor growth, including: (1) necrosis linked to deprivation of oxygen; (2) hypoxia-dependent VEGF induction and subsequent angiogenesis; (3) poor delivery of cancer drugs leading to their inefficiency; (4) hypoxia-dependent upregulation of several growth factors and cytokines; (5) tumor microenvironment shaping; and (6) adaptation of cancer cell metabolism. This evidence concerns the gene VEGFA and cancer.