Analysis of the TCGA database and the Cancer Immunome Atlas (TCIA) showed that M1 ccRCC patients with a low expression level of Plk1 and PDL1 had the longest OS, patients with a high expression level of PDL1 had an intermediate OS, and patients with high Plk1 and low PDL1 had the shortest OS (Supplementary Fig. 9a). This evidence concerns the gene PLK1 and nonpapillary renal cell carcinoma.