Analysis of the TCGA database and the Cancer Immunome Atlas (TCIA) showed that M1 ccRCC patients with a low expression level of Plk1 and PDL1 had the longest OS, patients with a high expression level of PDL1 had an intermediate OS, and patients with high Plk1 and low PDL1 had the shortest OS (Supplementary Fig. 9a). The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.