SETD2 and nonpapillary renal cell carcinoma: Consequently, ccRCC is a hypervascularized tumor that carries frequent mutations in chromosome 3p, which affects an array of chromatin-remodeling genes, including Polybromo 1 (PBRM1), SET Domain Containing 2 (SETD2), and BRCA1 Associated Protein 1 (BAP1)2,3.