Notably, these results are in alignment with reduced lipofuscin (autofluorescent POS-breakdown product) observed in CLN3 disease donor eyes13 (Fig. 2A, B and Supplementary Fig. 2), ERG recordings20,21 and the retinal imaging pattern64, (Fig. 9) in early stage CLN3 disease in vivo. The gene discussed is CLN3; the disease is glycogen storage disease VI.