CLN3 and glycogen storage disease VI: Specifically, with regard to POS phagocytosis, hiPSC-RPE cells from both CLN3 disease patient hiPSC lines used in the current study with the common 966 bp deletion spanning exon 7 and 8 when transduced with either pHIV-MYC-CLN3-IRES-EGFP or pHIV-FLAG-CLN3-IRES-EGFP for 5 days displayed increased POS uptake, as measured by RHO levels post 2 h POS feeding, compared to parallel cultures of untransduced CLN3 disease hiPSC RPE cells (Fig. 8E–G).