PPM1D and acute promyelocytic leukemia: The mutations were PPM1D (exon 6, 1 bp deletion) in malignant lymph node samples obtained 48 and 15 months prior to APL diagnosis from patient T2, and DNMT3A (exon 10, 1 bp insertion) in breast and lymph node samples both obtained 32 months prior to APL diagnosis from patient T11.