Columnar epithelial cell-associated transcription factors including CDX2, FOXA2, GATA4, GATA6, HNF4A, HNF1A, and SOX9 are aberrantly expressed in BE and EAC while stratified squamous cell-associated transcription factors including p63 and SOX2 are down-regulated in disease21–30. Here, GATA4 is linked to Barrett esophagus.