RYR1 and Malignant hyperthermia: Indeed, using the list of diagnostic RyR1 mutations, as defined by the European Malignant Hyperthermia Group (emhg.org), already 6 mutations are near the Nsol–Bsol interface, but many more have sequence variants, for which pathogenicity remains to be established, can be found in the same vicinity (https://gnomad.broadinstitute.org/).