Although Gal-9-binding proteins are also found on some other immune cells, such as myeloid cells56,57, our data show that Gal-9 inhibition in tumor-bearing mice selectively expands a subset of intratumoral TIM-3+ CD8 T cells and CD4 T cells, including immunosuppressive Treg cells, whereas the frequencies of myeloid cells were largely unaffected. Here, CD4 is linked to neoplasm.