IFNB1 and lung cancer: Interestingly, while IFNβ strongly induced Gal-9 in human lung cancer cell lines with wildtype EGFR (A549, H441, H1229), it failed to do so in those with mutant EGFR (H1650, H1975, HCC827) (Fig. 7f; Supplementary Fig. 8e), suggesting that IFNβ induction of Gal-9 expression may be affected by EGFR signaling in lung cancer cells.