Taken together, such mixed phenotype of CD8 T_1 is similar to what was observed in CD8 T cells that respond to other immune checkpoint therapies ﻿and are critical for tumor control6,10,48, and is indicative of transitory T cells in the process of differentiation from precursor exhausted T cells to terminally exhausted T cells8,33. The gene discussed is CD8A; the disease is neoplasm.