In contrast, the ALT-increasing allele rs58542926-T (TM6SF2) is associated with lower risk of dyslipidemia, the ALT-increasing rs429358-T (APOE) is associated with lower risk of ischemic heart disease and the AST- and ALP-increasing allele rs1260326-T (GCKR) associated with lower risk of diabetes. This evidence concerns the gene APOE and metabolic syndrome.