SERPINA1 and liver disorder: UKBB-specific variants included exonic variants in SERPINA1 (Supplementary Data 7) and HFE (Supplementary Data 5) responsible for the alpha-1 antitrypsin Z phenotype and hereditary hemochromatosis, respectively19,20, with a disease causing allele frequency of 0.02 and 0.08, respectively, in UKBB and are not present (monomorphic for the major allele) in BBJ, highlighting one reason certain liver diseases are more prevalent in certain populations.