In contrast, genes associated with cholangiocytes were more associated with cancer (CDH6, ST5), epithelial-mesenchymal transition (LRBA, TJP3), and stem cell-related phenotypes (RHPN2, HNF1B), consistent with prior reports that these cells form a class combined with EpCAM-expressing progenitor cells29. The gene discussed is DENND2B; the disease is cancer.