Among this group of 20 kidney cancer cell lines screened with 437 compounds of diverse mechanisms of action, we found EMT and apoptosis-caspase pathway ssGSEA scores most strongly correlated with sensitivity to cyclin dependent kinase inhibitors (CDKi; Supplementary Fig. S12c; Supplementary Data 11) and compared favorably to other classic therapeutic targets in RCC such as VEGF and mTOR inhibitors, consistent with the poor response of S/R RCC tumors to these agents2,33. Here, MTOR is linked to renal cell carcinoma.