In a sensitivity analysis excluding all BAP1 mutants (from the S/R and non-S/R RCC) groups, the immune findings reported in this study were found to be largely consistent with the results of the primary analysis, suggesting that the immune findings of the current study in S/R RCC tumors are not solely driven by BAP1 mutations (Supplementary Fig. S11). This evidence concerns the gene BAP1 and renal cell carcinoma.