Moreover, high MYC targets version 1 (v1) expression as quantified by single sample GSEA (ssGSEA) scores21 significantly correlated with worse clinical outcomes in both the subset of patients with S/R in the anti-PD-1 (nivolumab) arm of the CheckMate cohort as well as the subgroup of stage IV S/R RCC patients in TCGA independently (Fig. 2b; Supplementary Fig. S4; Supplementary Data 6). This evidence concerns the gene MYC and renal cell carcinoma.