RUNX1 and Dravet syndrome: DNA methylation in DS newborns at the top two DS-associated DMRs, in RUNX1 and FLI1, was not driven by the presence of GATA1 mutations; in fact, at both DMRs, which were significantly hypermethylated in DS newborns, the mean methylation levels were slightly lower in GATA1 mutation-positive than in wild-type DS newborns, albeit still considerably higher than in non-DS newborns (Supplementary Figs. 12 and 13).