RUNX1 and Dravet syndrome: This showed markedly lower expression of FLI1 in DS FL myeloid progenitors (P < 0.0001), consistent with hypermethylation of the FLI1 promoter in DS neonatal blood (Fig. 5b), while RUNX1 expression was increased in DS myeloid progenitors (P < 0.0001) compared to normal FL counterparts (Fig. 4b), perhaps reflecting the significant DMR hypermethylation found at the RUNX1 P2 promoter but not the P1 promoter in DS newborns (Supplementary Fig. 7).