We repeated linear regression analyses for the top significant CpGs in RUNX1 (cg12477880) and FLI1 (cg17239923), genes that are known regulators of hematopoiesis, adjusting for deconvoluted blood cell proportions instead of ReFACTor components (see “Methods”), and the associations with DS remained highly significant (both P < 2.0 × 10−16). This evidence concerns the gene RUNX1 and Dravet syndrome.