This showed markedly lower expression of FLI1 in DS FL myeloid progenitors (P < 0.0001), consistent with hypermethylation of the FLI1 promoter in DS neonatal blood (Fig. 5b), while RUNX1 expression was increased in DS myeloid progenitors (P < 0.0001) compared to normal FL counterparts (Fig. 4b), perhaps reflecting the significant DMR hypermethylation found at the RUNX1 P2 promoter but not the P1 promoter in DS newborns (Supplementary Fig. 7). This evidence concerns the gene FLI1 and Dravet syndrome.