Pathogenic variants in eIF2B subunits (EIF2B1, EIF2B2, EIF2B3, EIF2B4 and EIF2B5; MIM #603896)40, EIF2S3 (MIM #300148)41, EIF3F (MIM # 618295)42, EIF4E (MIM #615091)43–45 and EIF4G1 (MIM #614251)46 have been previously described to cause distinct neurological disorders. Here, EIF2S3 is linked to nervous system disorder.