We observed changes in behavioral assays measuring fear and anxiety in F1 and maternally derived F2 offspring, changes in corticosterone (CORT) levels in exposed females and offspring, and alterations in expression of corticotropin-releasing factor receptor type 1 (Crhr1), which plays a central role in the HPA axis response to stress28,29, in the PFC of exposed females and in the brain of their neonate offspring. This evidence concerns the gene CRHR1 and Anxiety.