p53 in turn is involved in a complex network of interactions with Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN), also an effective suppressor of cancer and a contributor to longevity, which in reciprocal cooperation promotes stability and transcriptional activity of p53, while p53 was reported to enhance PTEN transcription [35, 36]. The gene discussed is TP53; the disease is cancer.