In these analyses we found that the risk of the adverse outcome was increased at the rate of three to four times in patients compared with controls at a similar level of such factors as age, gender, baseline levels of CRP, total cholesterol, HDL, LDL, smoking, diabetes mellitus, dyslipidaemia, BMI, waist circumference and carotid measures of intima-media thickness and plaque (table 3). The gene discussed is CRP; the disease is diabetes mellitus.