There were significant differences in the mutational status of TET2, RHOA, IDH2, and TP53 among the pathological subgroups, and AITL patients were more likely to harbor mutations in TET2 (88%; P < 0.001), RHOA (65%, P = 0.001), and IDH2 (28%; P = 0.024) than in other types of PTCLs. This evidence concerns the gene TET2 and angioimmunoblastic T-cell lymphoma.