Additionally, it has been shown that activation of AMPK by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) blocks cardiac hypertrophy induced by several pro-hypertrophic stimuli, mainly through its inhibitory effect on the mTORC1 pathway [66, 67]. The gene discussed is PRKAA2; the disease is cardiac hypertrophy.