Antlanger et al. [16] reported PA/Ao ratio as a prognostic marker that is related to the severity of disease, and is also associated with some risk factors such as diabetes, atrial fibrillation, right-sided heart failure, Brain natriuretic peptide (BNP), and low Glomerular filtration rate (GFR), especially in women. The gene discussed is NPPB; the disease is diabetes mellitus.