TP53 and cancer: Indeed, p53 controls multiple metabolic pathways, including glycolysis and pentose phosphate pathway, lipid, sphingolipid, amino acid, ammonia, and iron metabolism, mitochondrial biogenesis, integrity and respiration, TCA cycle, and ferroptosis [49] in normal cells, suggesting that deregulation of any associated metabolic activities contributes to several cancer and non-cancer human pathologies.