TP53 and Familial prostate cancer: For example, USP10 interacts with G3BP2 to block p53 signal transduction, leading to poor prognosis in prostate cancer [27]; USP44 promotes the development of prostate cancer by stabilizing EZH2 [28], and USP2a enhances c-Myc expression via microRNA-related regulation and thus promotes tumourigenesis [29].