Interestingly, a recent research discovered that lactate produced by glycolysis of tumor cells in the tumor microenvironment activates mTOR pathway, thereby phosphorylating the transcription factor TFEB and inhibiting its nuclear translocation, thereby inhibiting the expression of ATP6V0d2 (vacuolar ATPase subunit) in macrophages. The gene discussed is ATP6V0D2; the disease is neoplasm.