For example, the three rate-limiting enzymes in the glycolytic pathway, including hexokinase 2 (HK2), phosphofructokinase 1 (PFK1), and pyruvate kinases type M2 (PKM2) acted as a hallmark of liver cancer and is responsible for the regulation of immune evasion via regulating by many mechanisms, such as the AMPK, PI3K/Akt pathway, HIF-1α, c-Myc and noncoding RNAs in HCC (hepatocellular carcinoma) [115]. Here, PKM is linked to hepatocellular carcinoma.