We obtained 8 immune genes identified as independent prognostic factors for pancreatic cancer (ITGA7, COL7A1, SP1, NCBP2, RBM14, DENND4B, LQK1, ZNF709) through single factor COX regression, Lasso regression, and multifactor COX regression, which significantly affects the prognosis of patients with pancreatic cancer (Fig. 3). The gene discussed is DENND4B; the disease is familial pancreatic carcinoma.