Meta-analyses of the cardiovascular outcome trials (CVOT) reported to date suggest that glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose transporter-2 inhibitors (SGLT-2i) reduce risk of atherosclerotic MACE to a comparable degree in patients with T2D [13]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.