In addition, germline genes and pharmacogenetics also profoundly affect the treatment of osteosarcoma, including genes related to drug transport and DNA repair, such as ABCC3, ABCB1, RFC1, GST family, ERCC1, ERCC2 and XPC. ABCC3, ABCB1, RFC1, and GST are genes encoding drug transporters, whereas ERCC1, ERCC2, and XPC are involved in the repair of DNA damage induced by cisplatin. This evidence concerns the gene ERCC2 and osteosarcoma.