FOXO1 and embryonal rhabdomyosarcoma: Genetically, ERMS is characterized by allelic deletions on chromosome 11, and the main genetic characteristics of ARSM are chromosomal translocation of 1, 13, and 2, 13, with the production of fusion genes PAX7-FOXO1 or PAX3-FOXO1, respectively, which dysregulate various genes that participate in cell transcription and differentiation, thus promoting carcinogenesis.