As is shown in Table 5, the test of interactions was significant for NIHSS (p for interaction = 0.0023), while the tests of interactions were not statistically significant for age, sex, history of hypertension, history of diabetes mellitus, history of hyperlipidemia, history of previous stroke, history of coronary heart disease, history of atrial fibrillation, current cigarette smoking, ischemic stroke subtypes, receiving treatment with intravenous recombinant tissue plasminogen activator and proton pump inhibitors treatment (p values for interaction were larger than 0.05). This evidence concerns the gene PLAT and diabetes mellitus.