In A375 melanoma cells, significant expression changes were detected at the mRNA level affecting nineteen genes (upregulated: CCL4, CDKN1A, CSF2, DDIT3, DNAJB4, EGR1, GADD45A, HMOX1, HSPE1, IGFBP6, IL1B, MDM2, NFKBIA, SERPINE1, SOD2; downregulated: ERCC1, HSPA1L, HSPA8, XRCC2; up to 9-fold; p < 0.05; Figure 3B: volcano plot; Figure 3D: table)). The gene discussed is HSPA8; the disease is melanoma.