LDLR and metabolic dysfunction-associated steatohepatitis: Depner et al. [33] reported that DHA has a greater ability to prevent hepatic inflammation, fibrosis, and oxidative stress compared to dietary EPA in a low-density lipoprotein receptor (LDLR) knockout mouse model of western diet-induced NASH; however, DHA supplementation does not promote full remission of diet-induced NASH [31].