NLRP3 and obesity due to melanocortin 4 receptor deficiency: The NLRP3 inflammasome seems to act as a sensor for metabolic danger signals (endogenous DAMPs and PAMPs) that accumulate during obesity, including saturated free fatty acids (FFAs), ceramides, high levels of glucose, uric acid, and Islet Amyloid Polipeptyde (IAAP) [27].