NLRP3 and infection: Endothelial cells become active participants and regulators of the inflammatory response in the event of inflammation or infection as they are among the first cells to come into contact with endogenous particles or microbes Taking into consideration the role of NLRP3 inflammasome in the human body, suppressing the NLRP3 inflammasome could be a new approach in depletion of hyperglycemic toxicity and averting the onset of vascular complication in people with T2DM.