Indeed, Ladwig et al. [25] reported Iba1+ microglia with a stellate or amoeboid morphology within sites of neovascularization after stroke; while Morrison and Filosa [26] showed that their morphological changes after stroke included both increased and decreased cell ramification, suggesting that microglia activation is a multistep, dichotomous, and stringently regulated process that results in several functional and metabolic subtypes. The gene discussed is AIF1; the disease is stroke disorder.