The recent Teddy (The environmental determinants of diabetes in the young) study that analyzed 5891 children at high genetic risk of both diseases found that T1DM autoimmunity usually precedes CD autoimmunity and the T1DM-associated islet autoantibodies (IAs) significantly increase the risk of subsequent CD-associated tissue transglutaminase autoantibodies [70]. This evidence concerns the gene TGM2 and Cowden disease.