The crucial step of glycolysis is the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate, which is catalyzed by glyceraldehyde-3-phosphate dehydrogenase (GAPDH); therefore, the amount of the active enzyme is of great importance for the energy metabolism of cancer cells under hypoxic conditions [8]. Here, GAPDH is linked to cancer.