GAPDH mRNA levels were also increased in tumor cells compared to those in C6 cells cultured in flask, so in C6 cells in the tumor, the level of GAPDH was increased 3-fold; in C6-kiGAPDH cells, 4.6-fold; and in C6-kdGAPDH cells it did not alter significantly from the level of GAPDH expression in cultured C6 cells but was 2-fold less than that in C6 cells of the tumor (Figure 5a and Figure S4b). The gene discussed is GAPDH; the disease is neoplasm.