GAPDH and neoplasm: In order to prove the critical role of GAPDH in the viability of tumor cells, we developed two cell lines on the base of parent C6 cells, C6-kiGAPDH (with enhanced GAPDH expression) and C6-kdGAPDH (with reduced GAPDH expression) using lentivirus constructs; the changes in GAPDH level in newly generated cells were proven with the aid of Western blotting (Figure S1).