JUN and neoplasm: In LA-treated cells, we observed downregulation of the proto-oncogene, JUN, and upregulation of the tumor suppressor genes KLF7 and FOXO4. Interestingly, LA treatment caused a reduction in the expression of cell adhesion molecules CEACAM1/M5/M6, which are considered biomarkers of tumor progression [83]; this may also indicate reduced proliferation.