SOD1 and type 1 diabetes mellitus: It is evident from the data shown in Table 1 that STZ-induced T1DM animals have significantly (p < 0.05) increased plasma nitric oxide (NO) and lipid peroxides (LPO) levels in their pancreatic tissue and reduced (p < 0.05) levels of SOD and GST, implying STZ enhances oxidative stress.