MLANA and melanoma: In particular, the NPs, made of biodegradable polymer, were individually packaged with two peptides usually expressed in melanoma cells: Melan-A/MART-1 (26–35 (A27L) major histocompatibility complex class I (MHCI) restricted peptide (MHCI-ag), and the limited peptide MHCII Melan-A/MART-1 (51–73) (MHCII-ag), directed towards the MHC class I and class II antigen presentation pathways.