The main finding of this study was that checkpoint blockade induced an influx of new T cell clones into the tumor tissue, which were identified as activated/exhausted tumor-specific CD8+ T cells (PD1+TIM3+CD39+CD103+); interestingly, the frequency of CXCR5+ Tfh was also increased after treatment [86]. The gene discussed is HAVCR2; the disease is neoplasm.