To specifically determine if the loss of cIAP1 in the endothelium was the critical compartment for the reduction of tumor colonies in the lungs, we crossed ciap1fl/fl mice with a tamoxifen inducible Cre line driven by the Cdh5 (VE-cadherin) promoter [32] (ciap1VEC). This evidence concerns the gene CDH5 and neoplasm.