MDM2 and neoplasm: There has been a significant effort to restore wild type p53 function [28] in tumors with mutant TP53. Phase 1/II clinical trials are ongoing investigating small molecule inhibitors APR-246 (eprenetapopt binds to p53 at two cysteine residues in the DNA-binding domain and stabilizes mutant p53), PRIMA-1 (p53 reactivation and induction of apoptosis) and MDM2 inhibitor AMG 232 that restores p53 tumor suppression by blocking the MDM2-p53 interaction [29].