Importantly, in a TCGA cohort of glioblastoma (GBM) patients, a core signature of PDGF-D-induced genes in NK cells was positively correlated with NCR2 and PDGF-D/NKp44 engagement downstream events were associated with greater overall survival [29], suggesting a potential impact of NK cell activation in brain tumors. This evidence concerns the gene PDGFD and glioblastoma.