They indeed showed that the presence of RF in Indirect Membrane Immunofluorescence (IMI) assays increases the IgM reactivity detection, while in the Immune Adherence (IA) assays, its presence reduces the detection of anti-membrane antibodies, thus suggesting that the presence of RF prevents the binding of anti-tumor antibodies to their target antigens on cancer cells [66]. The gene discussed is CD40LG; the disease is neoplasm.