BCL2 and B-cell chronic lymphocytic leukemia: They appear as crucial regulators of cellular procedures such as early B-cell development [45], cell metabolism and autophagy [46,47], of signaling pathways including the NFkB pathway [20,48], the Hedgehog (Hh) signaling pathway [49], as well as of key molecules in B-CLL such as BTK [50], TCL1A [51,52,53], BCL2 [54], TERT [55], and the heat shock proteins (HSPs) [56].