Furthermore, low miR-15a-5p and miR-16-5p levels, caused by 13q14 deletion, results in an upregulation of their target, TP53, which leads to increased levels of miR-34b-3p and miR-34c-5p, thus leading to reduction of ZAP-70 levels and its downstream pathways, as well as to an indolent B-CLL phenotype [68]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.