TP53 and B-cell chronic lymphocytic leukemia: Another important example of miRNAs regulation in B-CLL is the connection of miR-15a-5p and miR-16-5p with TP53 and both miR-34b-3p and miR-34c-5p–produced by genes located in chromosomes 13q, 17p, and 11q, respectively–and their relation to B-CLL pathogenesis and patients’ outcome.