This observation is in correlation with the decrease of CCND1 levels–an overexpressed gene in some human B-CLL cases–as miR-15a-5p and miR-16-5p target the 3′ UTR of CCND1. Moreover, a synergetic effect of miR-16-5p and chemotherapeutic agents was observed in the induction of apoptosis [102]. The gene discussed is CCND1; the disease is B-cell chronic lymphocytic leukemia.