MSN and cancer: While the presence of moesin, a cytosolic protein associated with unfavorable patients’ survival in various cancers, has already been reported in GBM [70], CLUS expression has been identified in breast cancer cells as an extracellular protein that, interacting with extracellular HSP90 protein, promotes tumor metastasis [82], or the overexpression of which induces chemotherapy resistance in human gastric cancer cells [83].