Of note (Figure 7) is the possibility that the cytosolic enzymes (found in MVs, Table 1a) are interconnected among themselves and also with DPYSL2, which is, together with VIME (also identified in MVs), a cytosolic protein not expressed in normal brain tissue, whereas its levels as well as those of VIME are significantly high in GBM [69]. Here, DPYSL2 is linked to glioblastoma.