NOTCH1 and cancer: Inhibits translation of the messenger RNA encoding the N-MUS oncogene; cyclin-dependent kinases CDK4 and CDK6; transmembrane receptor protein NOTCH1, involved in the signaling pathway of cancer stem cells; ubiquitin ligase MDMX, involved in p53 degradation; antiapoptotic protein BCL2; sirtuin 1 (SIRT1 gene) involved in p53 degradation; transcription factor E2F3; transcription factors involved in self-renewal of undifferentiated embryonic stem cells: NANOG and SOX2; an integral cellular glycoprotein that plays an important role in cell–cell interactions, cell adhesion, and CD44 migration