Chemotaxis of immunosuppressive cells (MDSCs, T-Regs, PDL-1+ mast cells) and CD8+ T-cell sequestration is enabled through the activation of the CXCL12-CXCR4 axis, and its interruption results in higher CD8+ T-cell infiltration and intra-tumoural density, especially when used in combination with immune checkpoint inhibitors. This evidence concerns the gene CD274 and neoplasm.