NLRP1 and Alzheimer disease: In contrast to the Brazilian cohort, SNP (rs12150220) on NLRP1 gene was found to be associated with AD in the Swedish cohort [58,63]; while NLRP1 gene expression in the unaffected skin of AD individuals was also found to be negatively correlated with AD severity as reflected by EASI index [71], indicating the intrinsic genetic variation of NLRP1 could be AD-related.