For example, several NOD2 gene polymorphisms were identified in patients with auto-inflammatory Yao syndrome, which presents with recurrent dermatitis and eyelid swelling like AD and allergic rhinitis, respectively [67,68], as well as NLRP3 and NLRP12 mutations in IgE-associated cold-induced urticaria [69,70] are potential NLR candidates that should be explored. Here, NOD2 is linked to Alzheimer disease.