The highest reduction in disease incidence was observed with both CFS that is produced by L. fermentum ATCC9338 on PKC and PP, which exhibited higher antifungal activities, as well as lower pH and high peptide concentrations, suggesting that the reduction in disease incidence may be due to the production of antifungal compounds, such as organic acids and bioactive peptides. Here, PRRT2 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.