Dysregulation of the PI3K/Akt pathway is implicated in several diseases and accumulating evidence indicates that deregulation of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in hepatocytes is a common molecular event associated with metabolic dysfunctions including obesity, MD, and the non-alcoholic fatty liver disease (NAFLD) [43]. Here, AKT1 is linked to Menkes disease.