CFTR and cystic fibrosis: The current CF prognostic strategies involve a combination of multiple biomarkers of disease, imaging modalities, including PFT, NPD, and sweat chloride, where therapeutic screening has relied on the improvement of CFTR’s ion transport function (NPD, sweat chloride) followed by a subsequent assessment of inflammatory or infection biomarkers, PFT, and/or lung imaging [25,55].