HLA-C and toxic epidermal necrolysis: Previous studies have found that HLA-B∗15:02 is an cause of serious adverse reactions in the skin induced by anti-epileptic drugs.[16] Carbamazepine non-covalently bind to proteins or peptides and are presented by MHC molecules after cellular processing, resulting in the HLA–restricted T cell activation.[17,19] Perhaps the mechanism of atorvastatin-induced TEN could be studied in the light of this study.