BGLAP and Osteopenia: However, other researches on animals have demonstrated the effects of electroacupuncture on osteopenia and OP through signaling pathways and gene expression regulation.[28–30] Fan et al[28] reported electroacupuncture stimulation at CV4, which activated the Wnt/β-catenin signaling pathway, increased serum ALP and BGP levels and BMD, affecting bone formation and promoting bone metabolism in rats with ovariectomy-induced OP.