Immunohistochemically, the tumor cells of systemic EBV+ T cell lymphoma of childhood are mainly positive with CD8 and TIA-1, but different from ENKTL is the negative expression of CD56 (Table 1).[19,20] Primary EBV infections are most common in children and adolescents. The gene discussed is NCAM1; the disease is T-cell non-Hodgkin lymphoma.